Regina Silveira graduated in Visual Arts from Universidade Federal do Rio Grande do Sul and later attained her master's degree and doctorate from the Universidade de São Paulo’s School of Communications and Arts (ECA), where she is a professor since 1974. She was awarded grants from the John Simon Guggenheim Foundation (1990), the Pollock-Krasner Foundation (1993) and the Fulbright Foundation (1994).
She showed at the 1st Havana Biennial, Cuba in 1984, the São Paulo International Biennial in 1981, 1983 and 1998, the 2nd Mercosul Visual Arts Biennial, Porto Alegre (2001), the Trienal Poli/Gráfica de San Juan, in Puerto Rico (2004) and the 6th Taipei Biennial (2006).
Her invitational group exhibitions include Re-Aligning Vision: Alternative Currents in South American Drawing at the Miami Art Museum (2001), Brazil Body and Soul, at the Guggenheim Museum, New York (2001) We Come in Peace… - Histories of the Americas, at the Art Musée Contemporain de Montreal (2004), The Shadow, at Vestsjaellands Kunstmuseum, in SorØ, Denmark (2005), Corpos em Movimento, at la Mediatine, Bruxelles (2005), Indelible Images at the Museum of Fine Arts, Houston ( 2005) and Phantasmagoria, a travelling exhibition organized by ICI (NY), in 2007.
In Brazil, her works were featured in Arte/Cidade (1984 and 2002), Emoção art.ficial (2002) Subversão dos Meios at Instituto Cultural Itaú, São Paulo (2003), and Projeto Paredes, at MAM, Museum of Modern Art, São Paulo (2004).
Solo exhibitions include:Projectio at Fundação Calouste Gulbenkian, Lisbon (1988); Masterpieces (In Absentia), at LedisFlam Gallery,NY (1993), Grafias at Museu de Arte de São Paulo Assis Chateaubriand – MASP (1996), To be Continued, at NIU Art Museum, Chicago (1997), A Lição at Brito Cimino Gallery, São Paulo (2003), Desapariencia (Estúdio), at El Cubo, Sala de Arte Público Siqueiros, in Mexico, DF(2003), In Situ at Centro Cultural São Paulo, Observatório, Octhagon Project, at the Pinacoteca do Estado de Sao Paulo (2006) and Sombra Luminosa, at the Museo de Arte Banco de la Republica, Bogotá, in 2007.
Selected installations related to specific architectures were Claraluz at the Centro Cultural Banco do Brasil, São Paulo (2003), Derrapadas at Centro Cultural de España, in Montevideo, Uruguay (2004), Lumen at Palacio de Cristal, Museo Nacional Centro de Arte Reina Sofía, in Madrid (2005), Irruption, at the Taipei Fine Arts Museum (2006), Mundus Admirabilis at the Centro Cultural Banco do Brasil, Brasília (2007) and Fictions at the Museu Vale do Rio Doce, Vitória (2007).
Recent national prizes are the Sérgio Motta Prize for Art and Technology (2000), the São Paulo Art Critics Association (APCA-SP) Prize for the exhibition Claraluz (2003) and the Bravo Prize for Visual Arts for Mundus Admirabilis (2007).